Joint contracture is reduced by intra-articular implantation of rosiglitazone-loaded hydrogels in a rabbit model of arthrofibrosis
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چکیده
منابع مشابه
Intra-articular decorin influences the fibrosis genetic expression profile in a rabbit model of joint contracture
OBJECTIVES The goal of this study was to determine whether intra-articular administration of the potentially anti-fibrotic agent decorin influences the expression of genes involved in the fibrotic cascade, and ultimately leads to less contracture, in an animal model. METHODS A total of 18 rabbits underwent an operation on their right knees to form contractures. Six limbs in group 1 received f...
متن کاملEffectiveness of rosiglitazone in reducing flexion contracture in a rabbit model of arthrofibrosis with surgical capsular release
AIMS Animal models have been developed that allow simulation of post-traumatic joint contracture. One such model involves contracture-forming surgery followed by surgical capsular release. This model allows testing of antifibrotic agents, such as rosiglitazone. METHODS A total of 20 rabbits underwent contracture-forming surgery. Eight weeks later, the animals underwent a surgical capsular rel...
متن کاملTreatment of Staphylococcal Joint Infection in the Rabbit by Administration of Systemic Antibiotics and Intra-articular Corticosteroids
Background/objective: Despite the present routine treatment of septic arthritis with antibacterial agents, articular damage is persistent and frequently leads to loss of joint function. The aim of this study was to assess the effect of intra-articular corticosteroids added to systemic antibiotics in the treatment of experimental staphylococcal knee joint infection in rabbits. Methods: Thirty r...
متن کاملEffectiveness of Methylene Blue in the Prevention of Stifle Joint Arthrofibrosis in Rabbit Models
Background: One of the major challenges in orthopedic surgery is the prevention of arthrofibrosis, which can besuccessfully alleviated in its early stages. Many studies suggest the administration of methylene blue (MB) as anaccessible and effective agent for the prevention of post-operation adhesions. The purpose of this study was to evaluatethe efficacy of MB in the preventio...
متن کاملMorphological changes in rabbit articular cartilages experimentally induced by joint contracture--in association with aging.
Morphological changes in rabbit articular cartilage induced by joint contracture were studied by light and transmission electron microscopy. The knee joint was plaster-immobilized for 3-9 weeks in the flexion position. Three different age groups of rabbits were examined, i. e. at the age of 1 month (young), 1 year (adult) , and over 2.5 years (old). In the non-treated groups, the surface of the...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research®
سال: 2018
ISSN: 0736-0266
DOI: 10.1002/jor.24068